Just discovered PrimeShred and I’m geeking out over the ingredient combo (caffeine + green tea extract + cayenne + theanine + tyrosine + rhodiola + DMAE + piperine). Instead of another generic “does it work?” thread, can we dig into how to get the most out of a stack like this and what to watch for?
Questions and ideas I haven’t seen covered:
- Timing/circadian strategy: If the goal is thermogenesis + focus, is there an optimal window (e.g., 30-60 min pre-training in the early morning vs. pre-fast cardio)? Anyone tried shifting dose timing with their chronotype to avoid sleep disruption?
- Synergy with cold or heat: Capsaicin + cold exposure is supposed to nudge brown fat activity in theory-anyone track body temp/skin temp or resting HR with a wearable to see if there’s an additive effect with cold showers or sauna?
- Tolerance and cycling: Caffeine and rhodiola can build tolerance. What cycling schedules actually preserve effects (e.g., 5 on/2 off, 3 weeks on/1 off)? Any rebound hunger or mood dip on off-days?
- Piperine interactions: Since black pepper extract can boost absorption by inhibiting some liver enzymes, how are you spacing this from other meds or supplements that you don’t want potentiated? Any best practices on timing away from thyroid meds, SSRIs/SNRIs, or antihypertensives?
- Gut comfort hacks: Cayenne + caffeine can be rough fasted. Anyone found food pairings (e.g., a little fat or casein) that preserve effects but stop heartburn/jitters?
- Women’s responses: Any differences across the cycle, especially luteal phase (caffeine sensitivity, sleep, water retention)? Adjusted timing or reduced dose that still feels effective?
- N-of-1 experiment design: Thinking of doing a two-week A/B with:
A) caffeine + theanine + placebo capsicum,
B) full PrimeShred,
matched calories/training, tracking: morning weight/waist, RHR/HRV, perceived exertion, appetite, sleep. What would you add to make this more rigorous at home?
- DIY vs. pre-made: Has anyone replicated similar effects using “whole food” inputs (strong green tea + chili/cayenne in meals + coffee + rhodiola) and seen comparable outcomes, or does the piperine-driven absorption actually make a noticeable difference?
- Mood/cognition angle: Tyrosine/rhodiola/DMAE are supposed to help focus-useful for fasted training or just extra jitters? Any COMT/CYP1A2 fast/slow metabolizers who’ve noticed distinct responses?
Would love real data points: wearables, before/after resting HR, sleep scores, appetite ratings, and any unexpected side effects. Also curious about the best dose-splitting strategy (single AM vs. smaller AM/early PM) to keep energy up without wrecking sleep.