There is much discussion around thermogenic pre-workout supplements, but specific comparison and analysis of their efficacy, safety, and ingredient interactions in the context of alternative healthcare is limited. I would like to open a discussion focused on identifying and evaluating evidence-based, lesser-known natural thermogenic compounds (beyond caffeine, yohimbine, or green tea extract) that can be used pre-workout, either in isolation or as part of a custom blend.
Which botanicals, adaptogens, or functional foods have substantial support for increasing thermogenesis or promoting fat oxidation during exercise? Are there synergies between certain traditional herbal extracts-such as Aframomum melegueta (grains of paradise), Paradoxine® (6-paradol), capsaicin analogs, or Citrus aurantium (bitter orange)-that have demonstrated clinical or empirical benefit for pre-exercise use, while minimizing cardiometabolic risk?
Additionally, what protocols or preparation methods (i.e., tincture, decoction, encapsulation) best preserve the thermogenic compounds’ bioactivity?
Would appreciate members’ insights on novel combinations, dosing strategies, and potential contraindications-especially for those with alternative or functional medicine backgrounds. Comprehensive citations or references to clinical trials are welcomed for further reading.