One key point worth highlighting is that many mainstream prenatal brands still rely on folic acid rather than methylfolate (L-5-MTHF), which is more bioavailable and better tolerated by individuals with MTHFR gene variants. Also, choline content in typical OTC prenatals is usually much lower than current recommendations, whereas practitioner-focused formulas often include doses closer to levels shown in recent research to support fetal brain development. Another frequent gap is omega-3s-these are usually absent or minimal in standard multis but emphasized in practitioner brands, often as separate high-quality DHA/EPA supplements. A recent review in the American Journal of Clinical Nutrition (2022) discussed these gaps, especially for choline and methylfolate. So, quality and clinical impact can vary significantly based on these formulation differences.